The Neuromodulation Research Center (NMRC) is a large collaborative entity that brings together University of Minnesota’s experts from neurology, neurosurgery, neuroscience, biomedical engineering, radiology and other disciplines that share a focus to advance the understanding of brain conditions and diseases and the neuromodulation therapies that improve them. The NMRC enables a unique “bench to bedside” experience that drives translational research and the University’s discovery and health innovation missions. Collaborations in the heart of Minnesota’s Medical Device Alley further enrich the center’s impact through external industry collaborations and the state’s MnDrive initiative.
Jerrold L. Vitek, M.D., Ph.D., is the Chair of the Department of Neurology, Director of the NMRC and Center Director of the University of Minnesota Udall Center of Excellence for Parkinson's Disease. Professor Vitek fosters a collaborative approach to projects that enable many funded initiatives. One of the main themes of the team’s research focuses on the medical and surgical treatment of movement disorders including Parkinson's disease, dystonia, and tremor. Studying the pathophysiology of these conditions from many perspectives reveals new potential treatment avenues. Similarly, we study the surgical therapy Deep Brain Stimulation (DBS) from many angles to reveal its mechanisms, improve its effectiveness, and develop potential new applications of this technology.
Our interdisciplinary team is funded by grants ranging from the National Institutes of Health (NIH), industry partners, and broader university sponsored projects. We collaborate with other groups around campus, including the Center for Magnetic Resonance Research (CMRR) and independent clinical and pre-clinical research groups. Some of our current projects include exploring the neurophysiological changes that occur as Parkinson's Disease progresses, how Parkinson's disrupts and affects sleep, novel patterns of deep brain stimulation, and examining the cognitive and cortical changes associated with Parkinson's. Our collaborative and interconnected structure enables our group to share resources and achieve multiple research aims.
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Dr. DeNicola teaches at both the University of Minnesota and Macalester College in addition to her research at the Neuromodulation Research Center.
2021 has been a busy year so far the the NMRC. Not least for the volume of publications: check out some of the NMRC's most recent papers:
Sanabria, David Johnson, Luke Yu, Ying Busby, Zachary Nebeck, Shane Zhang, Jianyu Harel, Noam Johnson, Matthew Molnar, Gregory Vitek, Jerrold. (2020). Real-time suppression and amplification of frequency-specific neural activity using stimulation evoked oscillations. Brain Stimulation. 13. 1732-1742. 10.1016/j.brs.2020.09.017.
Werning, Alec Umbarila, Daniel Fite, Maxwell Fergus, Sinta Zhang, Jianyu Molnar, Gregory Johnson, Luke Wang, Jing Vitek, Jerrold Sanabria, David. (2021). Quantifying Viscous Damping and Stiffness in Parkinsonism Using Data-Driven Model Estimation. 10.1101/2021.02.17.431730.
Yu, Ying Sanabria, David Wang, Jing Hendrix, Claudia Zhang, Jianyu Nebeck, Shane Amundson, Alexia Busby, Zachary Bauer, Devyn Johnson, Matthew Johnson, Luke Vitek, Jerrold. (2021). Parkinsonism Alters Beta Burst Dynamics across the Basal Ganglia–Motor Cortical Network. The Journal of Neuroscience. 41. JN-RM. 10.1523/JNEUROSCI.1591-20.2021.
Congratulations to Dr. Hafsa Farooqi on earning her appointment as a MNDrive postdoctoral fellow. The appointment recognizes Dr. Farooqi's contribution to seminal neuromodulation research. She joins a number of number of NMRC alumni, postdocs, and faculty member who have received this prestigious award. Her project information is briefly elucidated below:
Congratulations to Drs. Biswaranjan Mohanty and Lingling Yang (not pictured) who have been named MNDrive fellows in the 2020-2021 cohort. The funded award comes in recognition of their work advancing the field of neuromodulation from the MNDrive foundation which fosters research in a number of Minnesota's core industries. More information on the MNDrive website.